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Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer's disease, the physiological role of APP family members and their diverse proteolytic products is still largely unknown.
Although Aβ serves as a central trigger for AD pathogenesis, the physiological role of APP and the question of whether a loss of its functions contributes to AD are still unclear.
However, these data are inconsistent [ 3– 7] and the results cannot be easily transferred to high altitude physiology since hypoxia during aircraft travel is moderate (maximum corresponding to an altitude of 2,500 m) and sitting in a cramped position itself may be a central trigger for coagulation changes.
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Complement and Fcγ receptor (FcγR) effector pathways are central triggers of immune inflammation; however, the exact mechanisms for their cooperation with effector cells and their nature remain elusive.
Chronic immune activation is regarded as a central triggering factor for inflammatory rheumatic diseases.
The pixel trigger system allows to apply a set of algorithms for the trigger selection, and its output is sent to the Central Trigger Processor (CTP).
He believes that his worm experiment has pinpointed the location of the central trigger, he said.
The Central Trigger System (CTS) consists in implementing the coincidence between the four telescopes.
It is composed of two separate levels (L1 and the central trigger).
Modern imaging studies point, together with the clinical picture, towards a central triggering cause.
It is a central irony that the trigger for it all, the door-opener if you like, was the arrival in the late 90s and early 2000s of "mockney" films such as Lock Stock & Two Smoking Barrels and Love Honour and Obey, in which Primrose Hill types rubbed shoulders with proper hard-men such as Lenny McLean.
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CEO of Professional Science Editing for Scientists @ prosciediting.com