Sentence examples for central transducer from inspiring English sources

The Co-SMAD SMAD4 functions as a central transducer in the TGF-β responses.

Rad53 is a central transducer of DNA damage responses in S. cerevisiae and its phosphorylation is a hallmark of checkpoint activation [30], [31].

Smad4 is the central transducer of TGFβ/bone morphogenetic protein (BMP) signaling.

The present review will discuss β-catenin as a central transducer of numerous signaling pathways and its role in mammary development and breast cancer.

The mechanism underlying this response might involve ATM, a central transducer in the DDR, because ATM-deficient cells fail to regulate interferon during the response to genotoxic stress (Pamment et al., 2002).

However, this model of pathogenesis with calcium serving as the central transducer of myofiber death has remained a hypothesis, and although many biochemical lines of evidence support this hypothesis, it was not until the past few years that the use of mouse genetics allowed for a more definitive analysis of this 'calcium hypothesis'.

PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways are thought to be the central transducers of oncogenic signals in solid malignancies, and there has been a lot of enthusiasm for developing inhibitors of these pathways for cancer therapy.

The serine-threonine checkpoint kinases Chk1 and Chk2 are often described as the "central transducers" of the DDR and are activated by the ATM kinase in response to DNA breaks and ATR kinase by single-stranded regions of DNA and form the key link between the sensing kinases ATM/ATR and the cell cycle machinery.

In colorectal cancers constitutive pathway activity is caused predominantly by inactivation of its negative regulator APC, whereas the typical alteration in gastric and hepatocellular cancers is mutational activation of the central signal transducer β-catenin.

Overexpression of miR-199a significantly inhibited Smad4, which is a central cellular transducer of TGF-β signalling, significantly inhibited the ability of TGF-β to induce gastric cancer cell growth arrest and apoptosis, and promoted anchorage-independent growth in soft agar (Ref. 71).

Given that β-cat is the central signal transducer of the Wnt signaling pathway, we evaluated the effect of PDE5 inhibition on β-cat messenger RNA (mRNA) abundance and protein content, and stabilization in 293 T cells, to further assess the possible involvement of PDE5 in Wnt signaling.