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The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.
The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the monoazaspirocyclic structure as central template for nonpeptide RGD mimics.
Bosentan analogs consist of pyrimidine as the central template substituted with four substituents at positions 2, 4, 5, and 6, with sulfonamide attached to the 4-position of the central pyrimidine (Supplementary Fig. 6).
"Restorations are usually small projects, a few hectares in size, but now we are confronted with whole landscapes in which the reconstruction must start with the central template, the groundwater, and then the soil.
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A series of potent and selective factor Xa inhibitors was synthesized using various readily available amino acids as central templates.
A series of novel transition state factor Xa inhibitors containing a variety of lactam ring systems as central templates was synthesized in an expedient manner and allowed for a great deal of structural variability.
Bosentan and its high-affinity analog K-8794 contain many aromatic moieties composed of a central pyrimidine template with four substituents: a 2-pyrimidyl, a 4-sulfonamide, a 5-phenol, and a 6-hydroxyl (Fig. 3a).
Krakow is an undisputed architectural gem of central Europe; a template for Disney's fairytale city.
On command from the botnet's central controller, a template server supplies the actual content of the spam, along with junk text (often book or news article extracts) to fool spam filters which might, by now, be alerted to image-only emails being potential junk.
As a control for the efficiency of reverse transcription and RNA quality, some wells were prepared with specific oligonucleotides designed to amplify the 3′, 5′ and central regions of the template; in order to exclude genomic contamination, untranscribed RNA samples were loaded in two wells as negative controls.
The effects of pretreatment pH, temperature, and holding time on the subsequent enzymatic xylose and glucose yields were evaluated in two central composite experimental design templates: one for low pH (pH 1 to 4) and one for high pH (pH 10-13), at varying temperatures (100°C to 140°C) and holding times (0-10 min).
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