The expression of ROS1 was found in human cancers of the central nervous system, stomach, liver, kidney, and colon [ 6].
It is regulated by complex feedback between the stomach and central nervous system.
lung, colon and rectum, stomach, bladder, central nervous system and skin.
The oozooid has a complex body plan, including a gastrointestinal tract (incurrent and excurrent siphons, pharynx, stomach, intestine), central and peripheral nervous system, an endocrine system, as well as a complex hematopoietic system and extracorporeal vasculature.
Almost any organ can be affected; however, common extranodal sites include the stomach, Waldeyer ring, central nervous system, lung, bone and skin [5].
Analyses on specific cancer sites have reported excess numbers of laryngeal, primary liver cancer [ 8, 10], cancer of the prostate gland, nose and nasal sinuses cancers, stomach [ 9], central nervous system [ 11], and bladder cancers [ 12].
It was soon after reported in the central nervous system (CNS), the stomach, gastrointestinal (GI) tract and pancreas.
In a stepwise Cox multivariable analysis a low tumor mitotic count (with central assessment), location in the stomach, and adjuvant imatinib for 36 months were the most important independent factors associated with favorable RFS (P < .001 for each factor).
Abdominal anomalies are very common in this syndrome (multiple spleens, absent spleen, central or left-sided liver, small stomach, central or right-sided stomach, esophageal atresia, duodenal atresia, biliary atresia, intestinal malrotation); heart defects and abnormal bronchial morphology are also common [24].
