"The protein kinase, Plk1, concentrates on the central spindle during anaphase in mammalian cells.
This is derived from the central spindle during late telophase and is localized within the intercellular bridge during cytokinesis.
Signals from the central spindle are thought to be important for signalling the location of the cleavage furrow.
The kinetochores from the 16 chromosomes are organized in a stereotypic cluster encircling central spindle microtubules.
Jantsch-Plunger, V. et al. CYK-4: A Rho family GTPase activating protein (GAP) required for central spindle formation and cytokinesis.
Adams, R. R. et al. INCENP binds the aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.
Using C. elegans zygotes, Dumont and colleagues find that kinetochore proteins, including KNL-1, participate in assembly of central spindle microtubules for cytokinesis.
Some early versions of the revolver, known as "pepperboxes," featured multiple barrels in a single cylindrical unit that revolved around a central spindle.
Petronczki, M., Glotzer, M., Kraut, N. & Peters, J.M. Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle.
In such a model, larger kinetochores on the central spindle half are biased against, possibly because their interactions with spindle microtubules are never sufficiently strong to fully switch off the error correcting mechanism of aurora kinase.
Giet, R. & Glover, D. M. Drosophila Aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis.
