The phrase "central significance" is correct and usable in written English.
It can be used to emphasize the importance or key role of something within a particular context or discussion.
Example: "The central significance of this research lies in its potential to change our understanding of climate change."
Alternatives: "key importance" or "crucial relevance."
For an expectant and often alienated world, they are of central significance.
There's always one moment, one telling event that will go on to assume central significance in an argument that encompasses the globe and decades of history.
Peter Stothard in the Times Literary Supplement judged the book "striking for Blair's powerful sense of himself and his central significance, a confidence comfortingly undimmed by those parts of the past three years spent making money from motivational speeches".
There's credible weight behind "the central significance of jazz to our nation's history and values," as Wynton Marsalis, the artistic director of Jazz at Lincoln Center, put it in his opening comments.
Ellison said: If the MPS searches for all relevant material cannot reveal such reports of central significance to the issue of possible corruption in the Stephen Lawrence murder investigation, there must be serious concerns that further relevant material has not been revealed.
The central significance of the Sabbath for Judaism is reflected in the traditional commentative and interpretative literature called Talmud and Midrash (e.g., "if you wish to destroy the Jewish people, abolish their Sabbath first") and in numerous legends and adages from more-recent literature (e.g., "more than Israel kept the Sabbath, the Sabbath kept Israel").
Thus, Bcl-2 expossibly possibly may not be of central prognostic significance in cytotoxically treated stage III colon carcinoma.
Our knowledge of present and past human lifeways and food security in hyperarid lands is deepened by a study of the Kel Tadrart Tuareg of the central Sahara, of significance for current issues relating to food production and resilience in the face of expanding global populations and changing regional climates.
It is quite likely that other countries will follow the lead of Egypt, given its central and symbolic significance.
In the nonlesioned hemisphere, only the central area reached significance for increased theta.
If you want to suggest something so out of line with previous results you either need to rule out alternative explanations with more experiments or more honestly acknowledge/discuss why these results differ, especially when the claim is so central to the significance of the paper.
