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There is a high prevalence of reflux in asthmatics and chronic cough, which may be induced through different mechanisms including microaspiration and both local and central reflexes [ 18].
The presence of central reflexes are indicators of consciousness that are linked to functioning of the brain stem or spinal cord.
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Differences in the autonomic system activity may be due to differences in afferent receptor stimulation, in central reflex transmission, in the efferent nervous system and in post synaptic signaling.
The aims of this study were to examine cough triggers in individuals with chronic cough (CC), identify sensory symptoms consistent with central reflex sensitization (paresthesia and allotussia), and interpret this information in relation to sensory laryngeal neuropathy.
Furthermore, the proposed approach effectively works with non-fluorescein fundus images and proves highly accurate and robust in complicated regions such as the central reflex, close vessels, and crossover points, despite a high level of illumination noise in the original data.
We have recently reported evidence for laryngeal pesthesia in these conditions [ 7] as well as cross stimulus responses which strongly indicate underlying central reflex sensitisation.
Interestingly though, one of the most important features for the discrimination of arteries and veins by colour fundus images is the central reflex in the red color channel [ 3, 9, 10].
Due to the connection of the central reflex arcs in the brain stem and in the cortex with neurons within the spinal cord it seems likely that they are indirectly affected by NT.
The hypothesis is that because arteries carry blood rich in oxygen their inner part is brighter than their walls compared to veins, which makes the central reflex feature more obvious in arteries [ 3].
On the other hand, these central reflex arcs are also subject to other influences, such as emotions (for example, the doctor-patient relation), especially in the presence of the respective neuroplastic changes.
Development and reliability of retinal arteriolar central light reflex quantification system: a new approach for severity grading.
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CEO of Professional Science Editing for Scientists @ prosciediting.com