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As T-cell epitopes mainly reside in the central proportion of Aβ1 42[ 19], a number of approaches have been developed comprising the Aβ N-terminus (B-cell epitopes) to avoid a T-cell response and have shown promise as second-generation active immunotherapeutic options for modifying AD.
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Furthermore, from 1999 to 2002 in six hospitals in central Japan, the proportion of gonococcal isolates with decreased susceptibility or resistance to CFM (MIC ≥ 0.5 mg/L) and CRO (MIC ≥ 0.5 mg/L) increased from 0%toto 30.2 % and from 0%to0.9%.9 %, respectively [ 17].
As expected, the median number of central lymph nodes retrieved, number of central lymph nodes involved, and proportion of patients with metastatic central compartment lymph nodes (pN1a) were significantly greater in the CND-positive group.
In adult skeletal muscle of miR-133 dKO mice, a higher proportion of central nuclei was observed in type II (fast) muscle fibers, reminiscent of human central nuclear myopathy (CNM), a group of congenital myopathies characterized by abnormally centrally localized nuclei and muscle weakness [ 101].
The report also highlights the government's closer engagement with SMEs, with the proportion of central government direct spending with SMEs across all procurements - including ICT - on track to double, from 6.5% of direct spend in 2009-10, to 13.7% (year to date) for 2011-12.
Saying the proportion of central government procurement from SMEs has risen from 6% in 2010 to more than 10% now, Maude will add: "We know the best technology and digital ideas often come from small businesses but too often in the past they were excluded from government work.
The Ministry of Health and Welfare funding is earmarked for childcare, but local education offices are free to decide on the proportion of central funding to be allocated to kindergarten education.
Under the impact of the policy, the central region increased its proportion of minority population and the proportion of minority population in southeastern China increased by one percentage point.
Even though Central America represents only 3% of the worldwide coverage of teak plantations, the species is considered very important in the region and covers a large proportion of Central American forest land (Kollert and Cherubini 2012).
In addition, hydrogel based formulation promoted the antigen-specific CD8+ T cell immune memory as determined by the proportion of central and effector memory CD8+ T cells in nasal associated lymphoid tissue (NALT).
Although recent studies underlie the important role of trembling aspen (Populus tremuloides) in cavity networks of Canadian western temperate forests, limited information exists for conifer-dominated forests such as the black spruce (Picea mariana) forests of central Québec where the proportion of deciduous trees is generally <10%.
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