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Indeed, the fact that the domain-to-domain variability of evolutionary rates is considerably broader than in the null-model is one of the central observations of the manuscript.
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These are small steps, but they tie in with another, central observation of Kahneman's: that, faced by an attention-sapping situation and the escalating possibility of poor judgement, the best thing you can do is "recognize that you are in a cognitive minefield, slow down, and ask for reinforcement".
However, studies performed on a prototypic polycomb target promoter –the NGFR gene- corroborated our central observation of Bmi1 attenuation by SYT-SSX2.
A central observation of our in vitro study is that DEHP caused no deleterious effects.
The central observation of this study is that GSH can be directly nitrosated by DEA/NO-derived NO with high efficiency.
The central observation of this study is that GAPDH protein levels are decreased in both old and young muscle following I/R injury.
DOI: http://dx.doi.org/10.7554/eLife.03255.010 A central observation of the present study is that there is a transient increase in temperature sensitivity of Kv channels, which occurs when the voltage-sensor is partially decoupled from the activation gate.
A central observation of EDIC and UKPDS is, that diabetic people who were recruited early in their disease career (newly diagnosed to 5 years), despite of treatment modalities, first presented with microvascular disease only whereas macrovascular disease occurred much later.
I love its central observation (for the natural history of these islands is, indeed, eminently curious).
They concluded that "although the ranking of hospitals at extreme ends of the distribution are reasonably secure - there is considerable uncertainty about the ranking of more central observations," Nevertheless, the correlation coefficients of 0.88 to 0.96 between the original composite measure and four alternatives strengthened their basic concordance.
Mr. Sen's central observation was of the "thoroughly class-dependent character" of famine.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com