Transcription factor Foxn1 is a central mediator of the differentiation and function of TEC.
NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells.
Davalos, A.R. et al. p53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes.
Zhao P, Xu Y, Wei Y, Qiu Q, Chew T-L, Kang Y, et al. The CD44s splice isoform is a central mediator for invadopodia activity.
The transcription factor nuclear factor-κB (NF-κB) is a central mediator of growth and homeostasis for both normal and neoplastic cells.
The ubiquitin‐proteasome pathway is the central mediator of regulated proteolysis, instrumental for switching on and off a variety of signaling cascades.
As such, in Alzheimer's disease, phosphorylated tau protein, the major component of neurofibrillary tangles, is considered a central mediator of disease pathogenesis.
VEGF ranks as key inducer of angiogenesis and central mediator that promotes vascular permeability (Schmitz et al. 2006).
The three neurons for each distributed "leg" of the brain, along with a central mediator (artificial prefrontal cortex), helps the bugs live autonomously, adjust to changing conditions and remain self-aware.
Previously, TNFα has been implicated as a central mediator in the pathogenesis of silicosis.
As a central mediator of IR induced inflammation, complement is involved in the development of organ damage.
