Sentence examples for central manifestations from inspiring English sources

These data demonstrate that peripheral administration of an rAAV2 vector in adult MPS VII mice can lead to transgene expression levels sufficient for improvements in both the peripheral and the central manifestations of this disease.

The pathogenic mechanism of these manifestations, however, is likely to be different from that of central manifestations, and we therefore consider that the results obtained, illustrate the behaviour of the antibodies studied in the central and peripheral NP manifestations.

A large cellular infiltrate, predominantly macrophages, to the site of infection is a central manifestation of helminth infections such as, for example, F. hepatica [2] and Brugia malayi [14].

Of note, recent studies have demonstrated that anti-U1 RNP antibodies (anti-RNP) in CSF, but not those in serum, are associated with central neuropsychiatric manifestations in SLE and mixed connected tissue disease (MCTD) [ 12].

The request 'What are the central nervous system manifestations that have been identified in patients with p.R395C?' supplies us with the specific manifestations (Ataxia and Chiari Type I) for a particular genetic variant (see Table  4).

Furthermore, hCDR1 reduced brain pathology and improved behavior parameters in mice with central nervous system manifestations.

Central nervous system manifestations include increases in intracranial pressure and reduced cerebral perfusion pressure [2, 14, 15].

Children have a special susceptibility to atropine toxicity; even a small amount may produce severe central nervous system manifestations [9].

CV-related central nervous system manifestations, including stroke, brain hemorrhage, and encephalopathy, with impaired cognitive function are exceedingly rare [13, 16, 20, 45 50].

The design and conduct of clinical studies to evaluate the effects of novel therapies on central nervous system manifestations in children with neuronopathic mucopolysaccharidoses is challenging.

Using MPS I dogs tolerized to human IDUA as neonates, we evaluated intrathecal delivery of an adeno-associated virus serotype 9 vector expressing human IDUA as a therapy for the central nervous system manifestations of MPS I.