Sentence examples for central in the pathogenesis of from inspiring English sources

A number of studies had considered CGRP to be central in the pathogenesis of migraine as well as tension type headache (TTH) [3 6].

Aggregation and misfolded α-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD).

Pancreatic β-cell failure, which is central in the pathogenesis of diabetes, has been explained by autoimmune assault in type 1 diabetes (T1D) [1] and by glucolipotoxicity, amyloid deposition, insulin resistance, unfolded protein response (UPR), and endoplasmic reticular (ER) and/or oxidative stress in type 2 diabetes (T2D) [2]–[14].

Given their critical role in AMD and that oxidative damage to the RPE and inflammation appear to be central in the pathogenesis of the disease, we studied the effect of different HQ concentrations and durations of exposure on the regulation of MCP-1, VEGF and PEDF expression in RPE in vitro and in vivo.

Ammonia intoxication theory is central in the pathogenesis of hepatic encephalopathy (HE) [ 1].

Central in the pathogenesis of AoCLF, defective detoxification leads to life-threatening complications, including an aggravated hyperdynamic circulation.

However, no known virus has yet been conclusively demonstrated to be central in the pathogenesis of this malignancy.

Although frataxin role is not completely understood, frataxin deficiency has been suggested to sustain the increased oxidative stress, which is central in the pathogenesis of FRDA [ 38].