Sentence examples for central hallmarks from inspiring English sources

This author awarded more weight to "refractory to preventives" (2 points) or "refractory to abortives" (2 points) than to the other components (1 point each), primarily because refractory to preventives or abortives are central hallmarks of RCM.

Altered cell proliferation and genomic instability are central hallmarks in the case of colon cancer (Hanahan and Weinberg, 2000; Malumbres and Barbacid, 2009).

Therefore, cells lacking Cdc13p display the two central hallmarks of telomere uncapping, unstable chromosome ends, and activation of a DNA damage checkpoint.

A promising strategy to circumvent tumour heterogeneity is to focus on the central hallmarks of cancer, which are present in almost all tumours irrespective of the underlying molecular changes.

The syndrome is associated with multiple endocrinological and metabolic abnormalities, with hyperandrogenaemia and anovulation as the central hallmarks (The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, 2004a, b).

Known affectionately as the founding father of niche sub-genre ancestral soul, Boddhi's music uses spirituality as its central hallmark.

Metabolic reprogramming is a central hallmark of cancer, enabling tumor cells to obtain the macromolecular precursors and energy needed for rapid tumor growth.

But with the release of the CIA's torture report Americans can no longer turn their backs on disturbing and shameful effects of the trickle-down sadism that was a central hallmark of Bush 43's presidency.

Finally, and most importantly, WNT5a induces IFN hypersensitivity (see below), a central hallmark of psoriasis.

For example in pathogenic bacteria, secretion of effector molecules is a central hallmark of the host-pathogen interaction in establishing a successful infection.

Although the pathogenesis of OA is not fully understood, a central hallmark in this slow, chronic disease is progressive destruction of the articular cartilage.