Sentence examples for central gene from inspiring English sources

In this study, a gene's product is considered central (gene centrality) based on a high PPI degree and two other measures: betweenness (BW) and clustering coefficient (CC).

And because heredity only sets the stage for manic depression and schizophrenia, while environment opens the curtain, identification of even a central gene will provide limited answers.

These studies significantly focus efforts aimed at identifying central gene regulatory pathways that mediate atherosclerotic disease, and the identification of classification gene sets offers unique insights into potential diagnostic and therapeutic strategies in atherosclerotic disease.

To address this challenge, we developed a high-throughput reverse engineering strategy to analyze how thousands of specific perturbations (encompassing all point mutations in a central gene) impact both a specific edge (interaction to a directly connected node) and an overall network function.

During that time, he helped pinpoint the central gene that controls aging in brewer's yeast.

Gene network analysis of lupus BMMCs identified central gene regulators implicated in disease pathogenesis which could represent targets of novel therapies in human SLE.

Importantly, upstream regulator analysis with splenic samples showed increased z-scores activation values for relevant transcription factors of the IFN response (IRF1, IRF3, IRF5, and IRF7), and also central genes in IFN signalling (IFN-I, IFNAR, and STAT1).

Then, we questioned whether these categories show enrichment because of a distinct feature among positively selected central genes or because central genes tend to be enriched in these categories.

The other central genes were not informative in the available EB-TS cell lines, but were analysed in hES cells.

In humans, only imprinting of the five central genes is evolutionarily conserved, and the eight flanking genes are expressed biallelically in the placenta [9].

Consequently, we suggest that proximal promoters have contributed to human evolution by increasing participation of central genes in the evolutionary process.