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Both of these contain long intramolecular coiled coils, a "hinge" region at their central folds, and a nucleotide-binding domain (NBD), which is jointly formed by their N and C termini.
It has been shown structurally - and this was a real surprise for me and I think for most people - that kinesin and myosin have very similar central folds around the region where they couple nucleotide hydrolysis to piston-like motion, and are almost certainly derived from a common ancestor [ 91, 92].
Fold the bottom strand of ribbon over the central folds.
Continue folding each bottom strand over the central folds until you have a stack of squares.
The central folds should "accordion" to form eight pages, while the backsides of the outer sections should form the front and back covers.
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Characteristic interactions among Arg90 Trp171 Arg139 guide the C-terminal part outside of the central fold, implying that the eukaryote-specific C-terminal extension localizes on the outer side of the ribosome.
Tetratricopeptide repeat (TPR) motif containing co-chaperones of the chaperone Hsp90 are considered control modules that govern activity and specificity of this central folding platform.
Based on this central fold, the family is also termed LβH-superfamily and comprises not only acyltransferases but also Zn-dependent γ-carbonic anhydrases [20].
The CD has a relatively long tunnel formed by surface loops with catalytic amino acids extending from the central fold of the CD.
This whole stretch of the polypeptide chain forms a large "loop" on the periphery of the central fold (mainchain of residues 73 and 116 approach each other to within 6 Å).
The central fold on the protocone of upper molars, as well as the dichotomous branching pattern and the furrowed surface of the protoantler of Procervulus, place it close to cervids, either as the sister-group [ 16] or the most basal membership [ 17, 18] of the family Cervidae.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com