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Systemic and central exposure to local anesthetics has been attempted in other pain paradigms.
We also believe, on the basis of our observation that the estimation bias of the 10th and 90th percentiles was directed 'inwards' towards the overall central exposure value, that more extreme percentiles will be even more biased with limited sampling.
We hypothesized that the lack of protective effects of DMF on sEPSC duration in EAE mice could be related to a low central exposure of MMF after oral gavage (dose-limiting toxicity prevents testing higher chronic doses).
In this setting, there is strong a priori evidence that sun exposure or vitamin D, or both, is likely to be the central exposure 6 and little a priori evidence for any other strong determinant of multiple sclerosis likely to be linked to maternal ambient ultraviolet radiation exposure during the first trimester.
Similar(54)
Exposure mortality associations were generally smaller and nonsignificant in the Collaborative cohort, with some nonsignificant negative associations for central site exposure over the 31-day period.
The central tendency exposure assessment model successfully described the measured urinary arsenic concentration for the majority of children at the site.
In contrast, BW-25113+pU23 and all deletion strains displayed substantial but variable amounts of cleavage, suggesting varying degrees of central PK exposure.
Surprisingly, we found that deletion of RimP has a much stronger effect on central PK exposure than either RimM or RbfA, suggesting that RimP may have a more direct role in central PK formation.
Fourth, for the central monitor exposures we restricted the sample to mothers who lived within 10 km of the Harvard Supersite.
Thus, we are reasonably confident that for this panel study, the central-site exposure is an acceptable proxy for residential exposure of coarse PM.
For each central-site exposure period of interest, for each participant, we required that participants live within 40 km of the Harvard Supersite and that exposure data be available for at least 75% of the time in the specific averaging period; otherwise, the exposure was set to missing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com