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Indeed, despite the fact that there are several key phenotypes of SCD (anemia, stroke, infections), fetal hemoglobin (HbF) has emerged as a central disease modifier [3], that is amenable to therapeutic manipulation [6].
The main focus of our paper is to review the implications of the current approach to scoring CAC scans in terms of correlation with the central disease – coronary atherosclerosis.
Excessive activity of dendritic cells (DCs) is postulated as a central disease mechanism in Systemic Lupus Erythematosus (SLE).
We found a multitude of associations between disorders of the metabolic syndrome of which hypertension was the most central disease.
Patients with stage IVb disease are offered chemoradiation as a means of helping to control central disease, with radiotherapy for palliation of metastatic lesions.
Nevertheless, some surgeons suggest RFA may replace resection, especially in certain circumstances, such as new hepatic metastases after previous liver resection or limited central disease that would require extended hemihepatectomy.
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There is growing evidence indicating that neurogenesis in adulthood is influenced by certain types of the central diseases such as neuroinflammation, however, its mechanism is not fully understood.
HGMD has become the de facto central disease-associated mutation database available to the scientific community.
Agonists and antagonists of adenosine receptors have an enormous therapeutic potential for both peripheral and central diseases, including cerebral and cardiac ischemic diseases, sleep disorders, immune and inflammatory disorders, Parkinson's disease, epilepsy, and cancer.
Of course, the risk has to be evaluated individually, but patients with central diseases like stroke, PD, dementia and epilepsy and, for repeated falls, also patients with peripheral neurological disorders require special attention.
RyR1 point mutations can result in human skeletal muscle disorders such as malignant hyperthermia, central core disease, and multiple minicore disease.
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