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As in most oryzomyines, the central digit is larger than the two at the sides.
The central digit is notably larger than those at the sides.
However, autopodia of hoofed placentals follow a well-documented pattern of increased central digit emphasis in fore-and hindlimbs which is restricted to cursorial mammals [ 32, 52, 53].
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The hindfeet are long and have the three central digits longer than the two outer ones.
Finally, in the autopod of dcko forelimbs, only the central digits (typically digits 3 and 4) were formed, and like N-Myc mutants [25] they exhibited complete syndactyly with boney fusions (Fig. 8F and data not shown).
This convergence is interesting because emphasis of central digits often coincides with evolutionary trends in placentals towards cursoriality or bounding locomotion [ 37, 61].
The peramelemorph tarsal arrangement also appears in hoofed placentals, where it is considered to represent an adaptation to the emphasis on the central digits [ 15].
The fact that the formal teaching of this concept in Year 2, coincides with increased accuracy of estimation for central digits, lends further support to this argument.
Ectrodactyly involves the deficiency or absence of one or more central digits of the hand or foot and is also known as split hand/split foot malformation (SHFM).
We believe that these findings are highly relevant for the comprehension of the SHFM malformation, and we are tempted to speculate that the reduced expression of FGF8 and Wnt5a (our unpublished data) in the central AER of Dlx5 Dlx6 DKO limbs may induce mis-oriented divisions/movements of mesenchymal cells in this sector, hence altered morphogenesis/loss of central digits.
And he notes that this book's central figure, Nate Quinn, "loved watching creatures with four digits try to flip him the middle finger".
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