Sentence examples for central difficulties in from inspiring English sources

The central difficulties in constructing such information measures arise from the multiple, and sometimes conflicting, aims in practice.

The back-and-forth underscored one of the central difficulties in resolving the crisis: while opposition activists and armed groups refuse to negotiate until the government stops its crackdown, Mr. Assad's government says it has the right to respond with force to armed attacks.

The findings of this study demonstrate that one of the central difficulties in monitoring patient safety issues and preventing patient safety incidents for people with intellectual disabilities is the trend for reporting and monitoring those patient safety incidents that result, or could have resulted, in clearly defined physical harm.

But there was a central difficulty in winning over the Russians.

One central difficulty in the interpretation of volcanic fatality data, and likely fatality data pertaining to other natural hazards, is the major influence of a small number of incidents causing thousands of fatalities.

A central difficulty in evolution education is that many of the "classic" examples found in textbooks and other outlets (e.g., Darwin's finches, peppered moths, the evolution of horses) seem irrelevant to everyday experiences of most people (Hillis 2007; Thanukos 2009).

One central difficulty in defining clathrin-independent endocytic pathways has been the paucity of rigorously validated endocytic markers and pathway-specific cargoes.

Although the influence of genetic susceptibility to CRC is well documented, a central difficulty in the identification of the genetic factors influencing CRC is the inability to adequately cope with the phenotypic heterogeneity present in all complex diseases.

Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms.

Ms. Brown noted one of the central difficulties of keeping good teachers in the system by adding, "We could waste our time training you for two years, then you want to go to Scarsdale and take our training with you".

The central difficulty is that in a field it is possible to divide but in a ring it is not.