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A penetration index below 1 indicates a more central deposition of aerosol [32, 33].
Controlling for obesity may not exclude this cellular dysfunction of central deposition of fat.
The central deposition of particles in lungs has been shown to be enhanced in COPD patients (Bennett et al. 1997).
Besides being invasive, IT delivery results in a concentrated central deposition in the upper respiratory tract, where mucociliary clearance is predominant.
Therefore, central deposition of fat in early childhood, indicated by abdominal circumference, may contribute to an increased risk of developing hypertension later in life.
Specifically, the central deposition of excess weight has been proven to be a stronger predictor of risk of morbidity [ 6– 10] and mortality [ 11] in comparison with overall obesity, as defined by BMI alone.
Similar(53)
Follicles occasionally seemed to extend outwards into marginal sinuses and in two animals exhibited central collagen deposition.
Ziprasidone was associated with a lower propensity for weight gain and central fat deposition than olanzapine.
Furthermore, the increase in the waist to hip ratio of olanzapine treated patients suggests central fat deposition.
We also assessed visceral abdominal fat, because it was the most commonly reported direct measure of central fat deposition.
In conclusion, we found that ziprasidone was associated with a lower propensity for weight gain and central fat deposition than olanzapine.
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