Overall, our work places actin regulation and cell rigidity as central contributors to all stages of in the evolution of breast cancer, which opens new avenues of exploration when designing cancer-targeting therapies.
Yet, other dinoflagellates, like Symbodinium, are central contributors to the health of reef ecosystems as the symbionts of corals [ 4].
Women are central contributors to our economy and now comprise half of the paid labor force for the first time in history.
In this model, the contribution of astrocytes to oxidative stress within the CNS is comparable to that of the labeled macrophages and microglia together, thus identifying astrocytes also as central contributors to oxidative stress in the acute phases of EAE.
Inflammation is a central contributor to the pathogenesis of CF pulmonary disease.
In the healthy intestine, basal immune activation maintains barrier function and commensal microflora composition; however, excessive and uncontrolled inflammation likely represents a central contributor to the pathophysiology of the feed-induced distal enteritis in salmon.
"Peter Diamond is a central contributor to the intellectual life of the MIT economics department, to the scholarly community at MIT and to the national community of insightful policy analysts". Other members of the award committee are professors Bruno Coppi, John Dower, Arnoldo Hax and Robert Langer.
Mentors were not always a primary source of feedback or a central contributor to success.
OBJECTIVES: The burden of visiting pharmacies to fill medications is a central contributor to nonadherence to maintenance medications.Recently, pharmacies have begun offering services that align prescription fill dates to allow patients to pick up all medications on a single visit.
One notable example is tofacitinib, an inhibitor of the Janus kinase (JAK -receptor-associated signaling pathway, which is involved in cytokine-mediated activation of the immune system and is potentially a central contributor to autoimmune pathogenesis (Furumoto and Gadina, 2013).
