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It operated under heavy central constraints (eg, no hospital closures) and only weak incentives (poorly performing health providers were bailed out).
The model is based upon OCLTT with focus on temperature-dependent bioenergetics and aerobic scope as the central constraints.
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Two novel series of small-molecule RGD mimetics containing either a substituted pyridone or pyrazinone central constraint were prepared.
Although there were debates (Hedges et al. 1994; Hanushek 1994) surrounding the validity of these reviews, criticism rarely focused on what was actually a central constraint to their usefulness: the quality of the available studies they reviewed in terms of isolating causal effects.
This suggests that aerobic scope is not the central constraint on performance [ 9], and that additional factors influence fitness.
This explains why the central constraint proposed as the cornerstone of ageing processes is Orgel's error catastrophe (or sometimes Muller's ratchet).
According to Zangwill, a central conceptual constraint on ethical reasoning is the 'because constraint': when we judge something to be wrong (or to have another ethical property), we are committed to its having this property because it has some other property.
Maintaining optimal functionality in the presence of such external variability is a central evolutionary constraint.
Other times it is political constraints; central banks may be designed to be independent from politics, but that doesn't mean politics don't matter.
The self-adaptation strategy approach we propose in this paper can be reused in different systems since only its central pieces (properties, constraints, filters and the RTS) are system-dependent.
The subgroups analysis pointed out the advantage in lung sparing in all TV groups (small, medium and large) for all the evaluated dosimetric constraints (central lung distance, maximum lung distance, and V5Gy, p < 0.0001).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com