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The central confirmation of histopathological diagnoses is mandatory to include patients into the outlined study.
Response was assessed by the attending physicians in each participating institution, and no central confirmation was performed.
In conclusion, central confirmation of breast cancer receptor status is critical for the interpretation of clinical data from experimental trials.
Similar to the RTOG study, central confirmation of the histological diagnosis was required prior to study entry.
Biopsies of the primary tumor were collected for central confirmation of HER2 status and assessment of candidate markers in tumor tissue.
A haematoxylin/eosin-stained section of each block was prepared for central confirmation of the histological diagnosis and determination of the histological type and grade [ 23].
Similar(49)
In the current report, we demonstrate the utility of PCR-based multiplexed assays to accurately confirm ER, PR, and HER2 status and obviate the need for central IHC confirmation of subtype, while obtaining additional biomarker data on a diverse set of breast cancer-related genes.
The questions that the Democrats need to ask about the executive order should also be central to confirmation hearings for Trump's Supreme Court nominee.
After central radiological confirmation of tumor progression, an optional open-label option is offered to eligible patients.
Whilst culture is central to confirmation of the mycobacterium, PCR for TB may have a role in this patient population to help establish a diagnosis [ 40].
Patients enroll onto experimental clinical trials based on ER, PR, and HER2 status and, as receptor status is prognostic and defines treatment regimens, central receptor confirmation is critical for interpreting results from these trials.
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