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A central bottleneck is that most recurrently mutated genes in cancer are found mutated in fewer than 5% of patients and most individual variants are found at exceedingly rare frequencies.
There would be no one central bottleneck that could fail.
Distributed approaches also benefit from the local optimization that is independent of a central bottleneck.
The results provide strong evidence that machine learning techniques can bypass a central bottleneck that interferes with turning unstructured data into useful information.
This in contrast to for instance the EPIC theory [46], which assumes only peripheral bottlenecks, and the central bottleneck theory of [47], which assumes only a single central bottleneck.
While brain evidence for a central bottleneck in the frontal lobes has been reported before (e.g., [48]), the current fMRI results give evidence for an additional central bottleneck located in the intraparietal sulcus, corroborating multiple-bottleneck theories.
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Together, these pieces form a serverless file system that eliminates central bottlenecks.
These influences could evolve sequentially across multiple levels of a hierarchical decision, consistent with much prior evidence for central bottlenecks and seriality in decision-making processes.
If cross-modal and within-modal interference arise from the same central amodal bottleneck, individual cross-modal ABs should correlate with individual within-modal AB magnitudes.
We have previously shown that Hepatitis C Virus (HCV) interacts with highly central and bottleneck proteins in the human interactome and built a network model of molecular pathways that are co-deregulated during chronicity [ 2].
Previous analysis allowed us to identify central nodes (bottlenecks) with high topological network values.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com