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Results from the first 3,533 patients on the two monotherapy arms with ER+ tumors (by central assessment) and centrally assessed PgR and HER2 confirmed the results reported above from the local assessment of receptor status [ 18, 21], indicating that PgR status in ER+ tumors does not predict responsiveness to letrozole when compared with tamoxifen.
The NAO said decisions to award severance payments had until recently been subject to insufficient challenge and oversight with "little central assessment of the potential risks".
This is an important finding, and more than anything else in the report will serve to bring back some analytical sanity to the central assessment machinery.
Another strength is the central assessment of all A1C assays.
In several studies, discordant results were noted between IHC staining between local and central assessment.
The strengths of this study include central assessment of HR/Her2 status and the consistent timing of MRIs.
Similar(24)
Both the HIT2000 trial and the HIT2000 registry demand central assessments of central reference histology (available in 100%% of the cases), neuroradiology and CSF-cytology (complete and valid in 85 % of the patients).
Moreover, the 25 patients who had a local HER2-positive result (IHC or FISH), but negative central assessments of IHC, FISH and RT-PCR showed a smaller but nonsignificant hazard ratio toward greater benefit from trastuzumab.
In the IHC-negative patients, and in the 44 patients who had negative central assessments of IHC, FISH and RT-PCR, there were nonsignificant hazard ratios toward benefit from trastuzumab.
The intelligence crisis that erupted in 2010, which has not been previously disclosed, only underscores how central that assessment has become to matters of war and peace.
No central pathology assessment of the cancer samples was done.
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