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The two outer aromatic moieties typically feature salisaldehydes and the central aromatic moiety an o-phenylene-diamine or analog.
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Structural modification was undertaken to separate CCR4 antagonism from the cytotoxicity of the compounds by varying the central aromatic core and terminal aromatic moiety.
The first similarity is the aromatic moiety that modifies the 5-position of the central pyrimidine ring, which corresponds to the 2-methoxyphenoxy group in bosentan.
Subsequently, the attention was directed towards the central aromatic ring (Table 4).
In all three structures, the aromatic moiety of the different ligands is bound in a hydrophobic pocket formed by the side chains of Val44, Val48, Trp47, Val51, Val52, Phe71, Cys73, Ile108, Phe111, Trp138, Leu160 and Ala164.
Blue thermally activated delayed fluorescent (TADF) emitters were developed by linking a donor moiety to a triazine core via the ortho-position of an aromatic moiety.
Herein a bulge binding agent with novel wedge-shape topology of the aromatic moiety was designed and synthesized.
Typical CYP2D6 substrates generally contain a basic nitrogen atom and an aromatic moiety adjacent to the site of metabolism.
Alcohol 4a possesses only two binding points, imidazole moiety and an aromatic moiety B adjacent to it.
This may be due to the presence of N,N-diethylanilinium aromatic moiety.
The bactericidal activity of thiazolidinediones derivatives depends on the substitution on the heterocyclic thiazolidine ring rather than the aromatic moiety.
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