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The rate of confirmation of locally adjudicated outcomes by central adjudication was 94% for colorectal cancer (Curb et al, 2003).
9 An independent central adjudication committee, unaware of the group assignments, adjudicated all primary and secondary end points and major and minor bleeding events.
The appropriate role of central adjudication - which trials, which outcomes, what methods - deserves scrutiny and further study.
METHODS: We reviewed the literature concerning central adjudication and documented the experience of adjudication in several clinical trials.
Regulatory authorities, including the FDA, derive confidence in the validity of results when central adjudication is performed.
The purpose of this manuscript is to review the reasons for central adjudication and to discuss whether trials could be simplified by limiting or streamlining the adjudication process.
Similar(29)
Screened patients who were initially considered "inoperable" underwent central independent adjudication by a committee of experienced surgeons, or local adjudication in collaboration with an experienced surgeon.
Study design: This multi-center, open-label study, with blinded central outcome adjudication, randomized patients with new CVLs to twice-daily reviparin-sodium or standard care.
Study design: This multicenter, open-label study, with blinded central outcome adjudication, randomized patients with objectively confirmed VTE to receive either reviparin-sodium or UFH/OA.
No central, blinded adjudication of the outcome "death" is needed.
stated that the diagnosis of pulmonary embolism in our study is not based in a central, blinded adjudication of outcome.
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