The disadvantage of the method is obvious, i.e., the visual field of microscope is small and hence make the fringe center difficult to observe.
Altitude determine or complicate conditions of socio-economic development and human influence on normal life development, for e.g. the greater is the altitude, the less arable land is in disposal, the terrain has a high degree of slop, major centers are difficult to access, as well as the spread of innovations are very slow.
However, direct comparison between the ET rates of these two centers is difficult to achieve due to different protein scaffolds and redox partners.
In a national program struggling to implement care outside of the main urban centers, a difficult to access, potentially dangerous and neglected area like the Pool was not high on the priority list to commence treatment programs.
The associated thunderstorm activity became separated from the center of circulation, and early on June 1, the center became difficult to locate due to becoming disorganized.
Over all, Alaska's electorate, although certainly right of center, is difficult to pigeonhole.
Emergency laparotomy procedures have a high risk profile, but the currently available risk-assessment models for emergency laparotomy are either unreliable (eg, small sample size or single center study), difficult to calculate preoperatively, or are specific to the geriatric population.
Finally, the center became difficult to locate, and the depression dissipated later on September 11.
The next day, however, the center became difficult to locate and the system was no longer forecast to intensity.
Sarah's broad circulation center was difficult to locate until it began moving northeast east of Luzon on August 2, when it intensified to its peak intensity.
