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The most significant problems of Mr. Ashcroft's tenure have been centered largely on the F.B.I.
Mr. McClintock's campaign has centered largely on issues like immigration, the federal budget and states rights.
The rumors centered largely on Mitt Romney, the former governor of Massachusetts who ran against Mr. McCain in the primaries.
Opposition to mayoral control has centered largely in the teachers' union and its allies in the State Legislature.
Its culminating drama was Southern, nonviolent, and religious, and centered largely on King and his times — from 1954 to his assassination, in 1968.
Mr. Putin and Mr. Kim spent much of the day in negotiations, privately and with advisers, that centered largely on economic issues.
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Instead, it will most likely focus on its digital strategy, which centers largely on its Nook e-reader.
Mr. Mortimer's best book is probably "Clinging to the Wreckage," his 1982 autobiography, which centers largely on his relationship with his difficult, demanding and eccentric father.
Advanced economic functions center largely upon the acquisition and processing of information in various forms.
GGV's appeal also centers largely on the success it has enjoyed in China, a country to which many VCs flocked more than 10 years ago, then left, while GGV stayed put.
Figure 6 illustrates such a network that centers largely on such genes as THBS1, PITX2, ID1, RBL1 and INHBA involved in TGF-beta signaling pathways, linking cell cycle, cell communication and cytokine-cytokine receptor interaction pathways together.
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