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Our conclusion that the presence of a slowly dividing subpopulation of HSCs is the most likely explanation (amongst the various possible causes including stochastic cellular variation) of the observed long term Bromodeoxyuridine (BrdU) retention, is confirmed by the deterministic and stochastic models presented here.
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The persistence of cellular variation was determined by reculturing the sorted subpopulations in the presence of selection.
The discrete representation of the biomass phase yields an advantageous perspective for studying the impact of extra-cellular variations on the metabolism, but at significant computational cost.
The influence of extra-cellular variations on the organism can be tested using so-called scale-down simulators, laboratory scale setups where deliberate, controlled fluctuations are imposed in the extra-cellular environment.
This design principle is known as robustness and requires the system to employ layered control schemes that both buffer and exploit different facets of cellular variation.
A key collagenous constituent, Type I collagen, functions in neural crest cell migration and may be linked to the regulation of cellular variation.
However, one cell may include many instances of independent self-sustaining metabolic cycles and structurally transmitted cellular components, for example, increasing the repertoire of cellular variations that can be inherited via these forms of inheritance.
To some extent, these cellular variations may reflect different expression of various PHD isoforms in different tissues [ 5- 7].
Therefore, we examined these cellular variations induced by cisplatin in the presence of such biomimetic constructs.
Dynamic cellular automata are a variation of cellular automata that allows for movement of the cell contents inside the grid, mimicking brownian motion.
To ensure that the absence of staining was not due to regional variation of cellular distribution, the results were validated by repeating IHC analysis on full sections of cancer in selective cases.
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