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These data support the notion that cellular variation between target tissues is reflected in the stromal cells, and provide evidence for a link between an increased myofibroblast-like phenotype and high inflammation in the target tissue.
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For environmental chemicals, the extent of population variation in in vitro cytotoxicity may serve as a surrogate for cellular variation in the toxicodynamic relationship between systemically available concentrations and toxic responses (Zeise et al. 2013).
Robustness, noise, and cellular variation.
Shalek, A. K. et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.
Both measurement noise and cellular variation contribute to this distribution.
However this design does not completely account for the effects and efficacy that different components of the UV spectrum may have on different cellular targets, which may explain some of the variation between and within experiments.
General models of disease resistance show substantial variation between pigs and mice at the cellular and molecular level.
Alternatively, it could result from stochastic variation between cells in the activity of cellular signaling pathways.
As a whole CG rich regions show little variation between both cell states in line with continuous hypomethylation of CGIs during cellular differentiation.
Reduced variation between organizations.
There was huge variation between states.
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