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This design principle is known as robustness and requires the system to employ layered control schemes that both buffer and exploit different facets of cellular variation.
Both measurement noise and cellular variation contribute to this distribution.
The persistence of cellular variation was determined by reculturing the sorted subpopulations in the presence of selection.
Thus, cellular variation in the clone is predominantly non-heritable and reverts to a characteristic steady state.
Our conclusion that the presence of a slowly dividing subpopulation of HSCs is the most likely explanation (amongst the various possible causes including stochastic cellular variation) of the observed long term Bromodeoxyuridine (BrdU) retention, is confirmed by the deterministic and stochastic models presented here.
Analysis of the entire dataset using the network analysis tool Biolayout Express3D serves to highlight clusters of genes that share regulatory patterns across genetic and cellular variation.
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From that base, inter-domain and cell-cell communications enable genetic and cellular variations through self-referential natural informational engineering and cellular niche construction.
However, one cell may include many instances of independent self-sustaining metabolic cycles and structurally transmitted cellular components, for example, increasing the repertoire of cellular variations that can be inherited via these forms of inheritance.
Therefore, we examined these cellular variations induced by cisplatin in the presence of such biomimetic constructs.
To some extent, these cellular variations may reflect different expression of various PHD isoforms in different tissues [ 5- 7].
SMA is an aggressive, slow growing and locally invasive neoplasm characterized by two main histopathological growth patterns, the follicular and the plexiform, and by cellular variations that do not impact the clinical behavior [ 3].
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