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Furthermore, we observed that TAT contains a high percentage of mature adipocytes, 0.25% of macrophage cells, 15% of endothelial cells and a very low percentage of thymocyte cells, suggesting the cellular variability of TAT, which could explain the differences in gene expression observed in TAT.
Other sources of noise linked to cellular variability of the number of signaling molecules or other extrinsic noise emphasized by [ 23] would also lead to fluctuations in IFNB1 induction times.
Such findings of attenuated cellular variability of response under the circumstance of elevated input signal are consistent with previous experimental and computational results on the stochastic apoptosis pathway in genetically identical cells as well as other cellular processes [ 16, 22, 36, 51].
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The abundance of cellular variability throughout biological processes and the potential consequences of information degradation suggest that biological systems have developed mechanisms to regulate cellular variability.
While the costs and benefits of cellular variability are likely dependent on the specific physiological context, the functional significance of cellular variability suggests that cellular variability magnitude is regulated.
The origin of this cellular variability has been traced to fundamental properties of gene expression.
Our results demonstrate that spatiotemporal averaging of cellular variability is required for precision in organ size.
We found that regular organ shape results from spatiotemporal averaging of the cellular variability in wild-type sepals, which is disrupted in the less-variable cells of ftsh4 mutants.
Functional analysis of cellular response variability demonstrates that the observed cellular variability affects the core function of signaling networks.
Moreover, the abundances of c9p and c3p inversely regulate the cellular variability among the eight conditions.
However, the high costs and cellular variability are important limitations and represent crucial challenges, as does the issue of reproducibility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com