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We found that regular organ shape results from spatiotemporal averaging of the cellular variability in wild-type sepals, which is disrupted in the less-variable cells of ftsh4 mutants.
To illustrate the cellular variability in the stochastic response due to intrinsic noise, histograms of the steady-state CEA copy numbers in the same 150 cells is plotted in Figure 4B against different input CC levels.
Cellular variability in redox potentials is well-documented; for example, resting glutathione potential can range from -200 mV to -260 mV depending on cell type and culture conditions [ 2].
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These observations concur with previous reports on the interindividual and inter-cellular variability in sensitivity to NMDAR agonists such as glutamate or homocysteine.
The anthracyclines, doxorubicin and idarubicin, decreased cellular variability followed by a decline in both ΔΨm and ER integrity, suggesting these compounds are grossly cytotoxic.
Our results demonstrate that spatiotemporal averaging of cellular variability is required for precision in organ size.
Technological advances in single-cell measurement methodologies reveal substantial cellular variability.
(ii) For cellular variability, two cell lines TG1 and TG1_C1 were used.
However, the high costs and cellular variability are important limitations and represent crucial challenges, as does the issue of reproducibility.
However, cellular variability is not necessarily detrimental to cellular function.
Functional analysis of cellular response variability demonstrates that the observed cellular variability affects the core function of signaling networks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com