Exact(24)
Cells share information with each other via paracrine signaling, which effectively averages variable cellular responses and therefore reduces cellular variability.
We found that regular organ shape results from spatiotemporal averaging of the cellular variability in wild-type sepals, which is disrupted in the less-variable cells of ftsh4 mutants.
Our results demonstrate that spatiotemporal averaging of cellular variability is required for precision in organ size.
Furthermore, we observed that TAT contains a high percentage of mature adipocytes, 0.25% of macrophage cells, 15% of endothelial cells and a very low percentage of thymocyte cells, suggesting the cellular variability of TAT, which could explain the differences in gene expression observed in TAT.
However, cellular variability is not necessarily detrimental to cellular function.
While the costs and benefits of cellular variability are likely dependent on the specific physiological context, the functional significance of cellular variability suggests that cellular variability magnitude is regulated.
Similar(36)
These observations concur with previous reports on the interindividual and inter-cellular variability in sensitivity to NMDAR agonists such as glutamate or homocysteine.
As systems biology and personalized medicine are aiming toward reverse-engineering and re-engineering signaling networks, they are increasingly challenged by the inter-cellular variability and the large size of the relevant biochemical system.
This study slows the gelation rate of thiol-maleimide cross-linked hydrogels in order to overcome the cellular response variability between batches.
This study brings us one step closer to the broad goal of developing Prochlorococcus as a model for integrative systems biology — i.e. to understand its cellular architecture, variability, and the forces that shape the Prochlorococcus meta-population in the global oceans.
Population averaging due to paracrine communication can arbitrarily reduce cellular response variability.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com