Sentence examples for cellular validation of from inspiring English sources

This method enables cellular validation of the specificity of small molecule DUB inhibitors.

Therefore, the need for a thorough cellular validation of MELK inhibitors remains high.

Generation and Cellular Validation of shRNA Constructs Short hairpin RNAs for Tubb5 knockdown were cloned into the pSuper vector system according to the manufacturer's instructions VEC-pBS-0002 VEC-pBS-0002 VEC-pBS-0002

We agree with the need for virological and cellular validation of the R44/I45 mutations, which would support our structural and biochemical observations of the potential involvement of R44 and I45 in binding to AP1.

Cell based assessment tools and screening platforms are the preferred paradigm for small molecule identification and validation due to selectively identifying molecules with cellular activity and validation of compound activity against target proteins in their native environment.

Cellular and molecular validation of this model was conducted in three phases.

K.B. and J.S. carried out mouse behaviour, biochemical analyses and immunohistochemistry. S.L. did cellular immunoprecipitation and qPCR validation of microarrays.

The development of genetically modified rat models provides a valuable means of understanding the cognitive dysfunction associated with the loss of FMRP, as well as providing cross-species validation of cellular dysfunction that will strengthen the relevance of genetic models of FXS to the human disorder.

Statistics also plays a major role in organelle proteomics since the analysis of complex protein samples e.g. from sub-cellular fractions requires statistical validation of protein ratios.

Network re-engineering may serve as a useful tool in the elucidation and discovery of phosphorylation regulatory mechanisms as well as in the validation of observed cellular phenotypes.

After validation of our cellular models, we investigated the role of QSOX1 on proliferation, clonogenic capacities and invasion.