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Knockout lines of genes encoding vacuolar H+/Ca2+ transporters CAX1 and CAX3 were also analyzed to present perspective of other, non-plasma membrane, cellular transporter locations.
In brain, betaine cellular transporter BGT1 is present, but basal betaine concentrations are very low and a potential function of betaine is not known [ 39].
To exclude any potential involvement of cellular transporter systems, all experiments were conducted in parallel with artificial lipid vesicles (Fig. 3A).
Although in vitro and animal studies report that P-glycoprotein is not the main cellular transporter protein for efavirenz [ 18], several studies in African HIV patients reported association of genetic variation in ABCB1 with efavirenz plasma/intracellular concentrations and/or treatment outcome.
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In Phase III, conjugates are transported out of the cell by cellular transporters, e.g., ABC transporters (ABCs).
It is not known which solutes these springtail aquaporins transport and so they may not be the main cellular transporters or may act in concert with other transmembrane proteins.
These include the main cellular transporters of copper (copper transporter 1 (slc31a1), divalent metal transporter 1 (slcopper-transportingsporting ATPases (atp7a, atp7b)); zinc (various members of the ZnT (or slc30) and ZIP (or slc39) families); and iron (slc11a2, ferroportin (slc40a1)).
We discuss how lipid scavenging can be mediated via the reprogramming of cellular transporters at these interfaces and describe recent data suggesting that pathogen effectors modulate the formation of specific membrane contacts.
These nonthyroidal illnesses (NTIS) are the result of complex mechanisms that combine the effect of some drugs, cytokines, nutritional and endocrine factors at all levels of the thyrotropic axis, from the hypothalamus to the cellular transporters and nuclear receptors of thyroid hormones.
The integral membrane protein P-glycoprotein (P-gp, MDR1, ABCB1) is one of the most studied cellular transporters of the ATP-binding cassette (ABC) transporter superfamily [1].
Cellular transporters control the uptake, distribution and elimination of drugs.
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