The Rho family of GTPases regulate growth and cellular transformation processes78.
Do they have a role in all types of cellular transformation processes?
Justilien, V. & Fields, A.P. Ect2 links the PKCι-Par6α complex to Rac1 activation and cellular transformation.
Early during cellular transformation, low Src activity promotes stress fibre assembly and upregulates EVL.
Poli, V. & Camporeale, A. STAT3-mediated metabolic reprograming in cellular transformation and implications for drug resistance.
Dhawan, P. et al. Claudin-1 regulates cellular transformation and metastatic behaviour in colon cancer.
Zhao, L. & Vogt, P. K. Class I PI3K in oncogenic cellular transformation.
Maeda, T. et al. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.
Karnoub, A. E. & Der, C. J. Rho Family GTPases and Cellular Transformation.
Ridding them from cancer cells could forestall this cellular transformation and curtail the spread of tumors.
Is there a cross-talk between these factors during development and human cellular transformation?
