For screening potential cellular targets of the most drug-targeted network nodes (NOWADA), another systematic review of both original research articles and reviews was performed in PubMed database.
Endosomal-lysosomal system and mitochondria are the major cellular targets of ENMs.
Three of the cellular targets of these ribozyme sequence tags have been validated.
Cellular targets of these metals are mostly specific biochemical processes (enzymes) and/or membranes of cells and organelles.
The major cellular targets of UV-C are various biomolecules, which directly absorb this radiation or are indirectly affected by various UV-C induced photochemical reactions.
In spite of the major recent advances in retinoid biology, still there are many questions about the mechanism and cellular targets of this pathway.
Overall, these data established EPCs as new cellular targets of PAHs, which may contribute to the deleterious cardiovascular effects of environmental substances containing these chemicals, especially tobacco smoke.
Recently, the cellular targets of triptolide, such as MKP-1, HSP, 5-Lox, RNA polymerase and histone methyl-transferases had been demonstrated.
The major cellular targets of NFκB are chemokines, immune receptors, adhesion molecules, stress response genes, regulators of apoptosis, transcription factors, growth factors, enzymes and cell cycle regulators.
Among the prime cellular targets of mercury are mitochondria, and thimerosal-induced cell death has been associated with the depolarization of mitochondrial membrane, according to the International Journal of Molecular Medicine among several others.
Here we report the identification of cellular targets of these drugs.
