Exact(17)
A well-studied cellular switch is a protein called NtrC in the bacterium Escherichia coli.
Recently, I visited Verizon's cellular switch for the New York City metro area (disclosure: TechCrunch is owned by Oath, and Oath is part of Verizon).
The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to the active glucocorticoid cortisol, thereby acting as a cellular switch to mediate glucocorticoid action in many tissues.
In general, such a proposed molecular switch can become in addition a cellular switch if the responsible enzyme is working near substrate saturation [30].
Alternatively, there might be a molecular or cellular switch for anti-tumor immune responses or tolerance.
Such a cellular switch would be interesting to compare to other tumors and tissues, also in order to define a tumor specific therapy.
Similar(43)
The unifying theory had been found.No longer is the topography of cancer formless flesh, unbridled and invading, but a complex scaffold of cancer DNA that affords binding sites for molecular therapies to block or reset aberrant cellular switches.
Brewer and Nissen also have their eye on an experimental class of drugs that work on cellular switches that regulate the entry of fat into cells.
Our results suggest that cellular switching between high and low expression states and transcriptional re-initiation are important factors needed to accurately describe gene expression noise with a structured population model.
Down-regulated VEGF-A165b expression correlates with cellular switching to a pro-angiogenic phenotype that is associated with multiple pathologies including diabetic retinopathy and several adult epithelial cancers [ 18, 19].
Furthermore, since all cellular players maintain the immunologic balance of any localized ecology, changes in the composition of the cellular participants could significantly affect the likelihood of an infectious trigger or the initiation of the cellular switches that allow proliferation of malignant cells or the mutations that facilitate it.
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