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Therefore, p53, a cellular stress responsive transcription factor, plays a major role in exosome machinery and release while under microenvironmental stress.
We subsequently investigated whether SAPK/JNK, a major cellular stress responsive protein induced by oxidative stress, plays an important role in NK-4-mediated effects in PC12 cells.
CUGBP activity, LIP, and CHOP are cellular stress responsive and induced by TNFα.
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These conditions evoke a range of cellular stress-responsive pathways, including cytoprotective or cytodestructive branches.
ROS also elicits a cellular stress response, which may induce stress-responsive phosphatases, such as the MKPs, to serve as negative regulators of excessive MAPK activity [ 54, 55].
Taking inspiration from naturally occurring systems, biosensor functions are based on highly diverse mechanisms including metabolite responsive transcription factors, two component systems, cellular stress responses, regulatory RNAs, and protein activities.
To date, 129 p53-responsive genes have been identified that encode proteins, which mediate a wide variety of cellular stress responses [3].
Moreover, the level of the stress responsive gene CRP that is activated in dying cells [ 32] remains low in both control and irradiated cells, which suggests the absence of cellular stress response.
Cell death-related pathways participate in the cellular stress response.
The topic of this year will be cellular stress responses.
Reovirus induces and benefits from an integrated cellular stress response.
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