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A newly revealed cellular strategy for modularizing function inspires engineers.
RNA interference (RNAi) is a newly discovered cellular strategy for silencing genes in a sequence-specific manner [1 3].
However, to cope with the FA toxicity, tomato plants develop a cellular strategy involving activation of various enzymatic antioxidants.
Another cellular strategy for the insertion of the correct metal cofactor into metalloproteins (metallation) is compartmentalization. Therefore distinct metals are stored at different subcellular compartments and controlled delivered to their final destinations via specific transport systems (Tottey et al. 2008).
Many reports have suggested that posttranslational modifications are an important cellular strategy that enables the cell to react to intracellular or environmental changes caused by exposure to stress factors such as hypoxia [37], [41].
In addition, we show that unlike in other organisms, [22] [23], M. extorquens AM1 induces its metabolic pathways in a reverse order (biomass cycles first before the pathways that generate the biomass precursor metabolites), which may be a cellular strategy to prevent the buildup of downstream toxic metabolites.
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Further engineering and characterization of synthetic organizational systems will allow us to better understand native cellular strategies of spatial organization.
Among other evolutionary aspects, cellular strategies for the construction of novel functional codes via the intermixing of informational architectures could be related to the persistence of retro-elements with obvious viral ancestry.
To control and manipulate cellular signaling, we need to understand cellular strategies for information transfer, integration, and decision-making.
Modulation of gene expression plays a key role in cellular adaptation to short- or long-term changes [1], with gene expression responses to different stresses substantially advancing our understanding of the cellular strategies used for adaptation and survival.
In addition, this work has uncovered key candidates for regulatory control points, as a further step towards understanding metabolic adaptation and the cellular strategies employed to maintain metabolic setpoints.
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