Exact(6)
Cells cultured on planar controls did not undergo contact guidance, resulting in greater cellular spread and more mature adhesions.
Cells cultured on planar controls showed a near uniformly spread morphology with significantly fewer focal complexes (associated with cellular spread) and more mature adhesions than on grooved substrates.
If MET is constitutively activated, it would need only additional EGFR activity to induce cellular spread, according to the network model.
293T cells overexpressed MR-1, and cellular spread and invasion were enhanced after transfection of the pMX-MR-1 plasmid, suggesting that MR-1 is critical for ovarian cancer cell growth.
Because CCR5 functions in signaling pathways that promote chemotaxis, lower expression of CCR5 may reduce chemotaxis of macrophages and other target leukocytes toward infected cells and slow cellular spread (Locati et al. 2002; Ma et al. 2005).
In addition, we show that Cdh1 was phosphorylated by glutamate treatment, and that this was accompanied by cellular spread of PFKFB3 from the nucleus to cytosol in a Cdh1-inhibitable process; interestingly, the PFKFB3 mutant form lacking the Cdh1-recognizing KEN motif spontaneously accumulated.
Similar(54)
Cellular spreading (asterisk) was frequently observed, and multiple round projections on the cellular surface were noticed in the 4-hexylresorcinol-incorporated 4-hexylresorcinol-incorporated 4-hexylresorcinol-incorporated
Addition of gelatin to the PLGA freeze-cast constructs led to an increase in the average diameter of pores, hydrophilicity and cellular spreading.
However, this effect is mediated by cellular spreading on the extracellular matrix [41].
During the encapsulation of parasitoid wasp eggs, integrin recycling may be necessary for proper cellular spreading and adhesion, again integrin would be needed at the periphery of the spreading cells.
Enhanced cell spreading was even more pronounced in the presence of the KKDC peptide (50 µM), where multiple focal contacts appeared (Fig. 2, lower panels, KKDC), indicating that syndecans clustering by the KKDC peptide facilitates cellular spreading.
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