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Tanzi, R.E., Wenniger, J.J. & Hyman, B.T. Regional distribution and cellular specificity of APP alternative transcripts are unaltered in Alzheimer's disease and control hippocampal formation.
The two-subunit GluCl/IVM system permits "intersectional" strategies designed to increase the cellular specificity of silencing in transgenic animals.
The structural implications for the mechanism of action and cellular specificity of both Cry and β-PFT type parasporins will be enhanced by further experimental validation.
By making simultaneous measurements of the metabolic activity of different cell types seeded on different segments of one sensor, this device not only provides a rapid means of assessing cellular specificity of pharmaceutical compounds but also has the potential of being used to non-invasively monitor humoral as well as synaptic communication between different cell populations in co-culture.
injections of TGF-β1 TGF-β1 cellular specificity on phospho-p38 expression in neuropathecellularuspecificity immunofluorescent staining.
TGF-β1 on the cellular specificity of phospho-ERK expression in neuropathic rats using double immunofluorescent staining.
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The purpose of this study was to define the cellular specificities of HIF-1alpha and HIF-2alpha in retinal ischaemia, and to determine their correlation with the pattern of retinal hypoxia and the expression profiles of induced molecular mediators.
The purpose of the present study was to compare the cellular specificities of HIF-1alpha and HIF-2alpha in retinal ischaemia, and to determine their spatiotemporal correlation with retinal hypoxia and the expression profiles of induced molecular mediators.
The evidence presented suggests that yeasts may be a powerful model for the screening/development of PCD-directed drugs, overcoming the problem of cellular specificity in the design of antitumour drugs, but also enabling the design of efficient antifungal drugs, targeted to fungal-specific apoptotic regulators that do not have major consequences for human cells.
However, many of these earlier studies did not exclude a role for stimulation of fibers of passage, and lacked the cellular specificity and spatio-temporal resolution of the methods employed here.
Primary transcription is the major driver of cellular specificity, with splicing playing mostly a complementary role; except for the brain, which exhibits a more divergent splicing program.
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