The expression profiles indicate that the cellular responsiveness shifts from the micronutrient responsive receptors VDR and RAR to the hormone responsive receptors AR and TR, all of which have been reported to control adipogenesis and lipid accumulation [31]; [31]; [31]; [31].
mTOR has a pivotal role in cells survival and inflammation,18 while mTORC1/mTORC2, 2 distinct multiprotein complexes, may play different roles in cellular responsiveness.18 Our data demonstrated that mTORC1/mTORC2 was responsible for mediating BM-MSC-directed inflammatory modulation and anti-apoptosis effects in sepsis.
While PMN are beneficial through appropriate responsiveness to chemotactic factors released by infection and bacterial phagocytosis, our data suggest that excessive induction of neutrophil-MDSC will suppress T cell responses by downregulating the zeta-chain compromising cellular responsiveness.
These findings provide a new mechanistic understanding of how different FKBPs regulate the cellular response to rapamycin and points to the level of FKBPs as the rate limiting factor determining cellular responsiveness to rapamycin.
Connolly, T. M. et al. Species variability in platelet and other cellular responsiveness to thrombin receptor-derived peptides.
The consequences of this synaptic bombardment on cellular responsiveness are investigated in the companion paper.
Mukai A, Yamamoto-Hino M, Awano W, Watanabe W, Komada M, Goto S. Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt.
These studies indicate that CYP24 inhibition can increase cellular responsiveness to vitamin D hormone and potentiate vitamin D therapy.
Model neocortical pyramidal neurons were investigated to evaluate the impact of correlated synaptic bombardment on cellular responsiveness.
These interactions adapt cellular responsiveness to environmental conditions, but their complexity presents a daunting challenge to drug design.
A recent study on an hPSC-based 2D gastrulation model demonstrated a direct connection between cell density and the spatial localization of cell surface receptors for transforming growth factor-β and BMP signaling, wherein high cell density facilitates the seclusion of receptors to cell cell contact and thus suppresses cellular responsiveness to soluble ligands14.
