To further investigate the observation that Wnt1 induces amplification of the mammary myoepithelial compartment, we characterized the cellular response profile to Wnt1 expression using both β-catenin IHC and a β-catenin/TCF-responsive reporter strain, Axin2NLSlacZ.
Because the challenge is greater in the absence of cellular response profiling of drug combinations, we needed to find common features from their respective response data.
To reduce ADR-related morbidity and mortality, several computational attempts to identification potential ADRs have been made, including: I) generating various drug-related profiling (e.g., chemical profiling, cellular response profiling) to predict ADRs at different levels.
Overall, the promoter activity based cellular response profiling approach successfully identified a distinct set of promoters downstream of individual pathways (~80% of the promoters), as well as a set of commonly affected promoters.
It has also been shown that the relationship between APCs and T cells appears to be compromised by these polymorphisms in the IFN- γ pathway, via direct influence on the induction of cellular immune response profiles [ 46].
Thus, different stages of TB may be characterized by a particular antibody or cellular immune response profile against several antigens.
These cover a range of disciplines including allergy, immunology, cell biology and histology and include methods to investigate the cellular response to allergens, cytokine profile, MHC restriction, T regulatory cells.
However, at 9 and 12 h of Cry11Aa toxin exposure we saw a strong cellular response and a similar profile of enriched biological functions.
Although TLR2 and TLR6 are thought to be similarly involved in immune cell stimulation, the gene expression profiles and cellular response may be different than activation through TLR4.
Predicting the synergistic effects of drug combinations using the quantitative gene expression profiles of cellular response to drugs is challenging.
