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Further work, using rescuing transgenes or under endogenous or tissue-specific control, will be required to fully define the cellular requirements for BH4 synthesis.
Such a modular design could easily adapt and evolve to respond to different cellular requirements.
Little is known about the cellular requirements for infection in either host.
However, the mechanism and cellular requirements that govern PrPSc-mediated conversion of PrPC remain unclear.
UBDs then would mostly contribute to the enzyme regulation in response to cellular requirements rather than to strict substrate recognition.
Hence, the alleles can be used in future somatic experiments to assist in determining the cellular requirements of Smn.
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Some of these methyl groups are removed by demethylases such as ten-eleven TETnslocation (TET) proteins hence causing these methylation marks in the DNA to be reversible and dynamic in nature as per the cellular requirement and the environment (Auclair & Weber, 2012) (Fig. 1).
Strong induction of delta-7 and -9 desaturase activities in knockdown cells may, therefore, be secondary to enhanced cellular requirement for unsaturated FA species.
Mice deficient in both SphK1 and SphK2 are not viable, indicating an essential cellular requirement for S1P in addition to its role in inflammation [16].
Our interpretation of these results is that mutations in SEC9 affect a constitutive function, but that the temperature-sensitive phenotype is a manifestation of greater cellular requirement for this absent function under the increased physiological demands of higher temperature.
Consistent with the results for other tumors [16], [28], some amino acids, such as glutamate, ornithine, glycine, and pyroglutamate, were found at higher levels in UCML compared with those in HC, which indicates a cellular requirement for a higher turnover of structural proteins.
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