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VR studies in epileptic patients along with cellular recordings showed hippocampal neuronal firing for specific places [35].
Cellular recordings in the hippocampus in relation to spatial memory while rodents are freely moving in natural-like environments such as mazes have revealed insights into complex brain-behavior relations [33], [34].
This conclusion was based on cellular recordings in animals exhibiting thalamic oscillation in the 8 12 Hz, and further studies which revealed a substantial relationship between rhythmic thalamic activity and distributed cortical activity [18], [32].
For full details of gamma oscillation detection and cellular recordings, see Supplementary Materials.
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Many electrophysiological experiments on neurons, namely extra-cellular recordings, are only capable of detecting the time of the spike and not the detailed voltage trajectory leading up to the spike.
Spike arrival times were obtained by thresholding the extra-cellular recordings with a custom-made time- and level-window discriminator [52].
Furthermore, the cells generating this rhythm exhibit stereotyped dynamics and can be identified by visual inspection of intracellular recordings and comparison to simultaneous extra-cellular recordings of identified nerves.
Translated to the case at hand this may signify that the LP neurons may actually be much more similar than it would appear from intra-cellular recordings of the control behavior.
We first performed extra-cellular recordings of field excitatory postsynaptic potentials (fEPSPs).
In contrast, the study of neural coding, lead historically via intra-cellular recordings of neural activity, has opened the door to breaking down many cognitive functions into atomic steps implemented by ensembles of neurons.
One of the advantages of this general approach is that estimates of functional connectivity can be made using signals from a number of different recording techniques from extra-cellular unit recordings [6], [7] and calcium imaging [8] to local field potentials [9] and fMRI [10].
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