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Fifty genes found activated predominantly in non-basal-like types of breast cancers were enriched for neuronal projection/differentiation and ossification, suggesting potential links to regulation of cellular processes regulating bone and nerve development in other breast cancer subtypes (Additional file 10).
This chapter discusses how various cellular processes regulating the oncogenesis can be targeted by small molecule inhibitors.
These shared functional properties suggest that specific cellular processes regulating normal stem cells may be active within CSC and serve as potential therapeutic targets.
CPD1 (also known as ANP32-E) belongs to a family of evolutionarily conserved acidic proteins with leucine rich repeats implicated in a variety of cellular processes regulating gene expression, vesicular trafficking, intracellular signaling and apoptosis.
This suggests that disruption of cellular processes regulating protein homeostasis, rather than cell death, could cause muscle degeneration in OPMD.
To examine cellular processes regulating phenotypic changes, we treated MCF-7 cells with selective inhibitors affecting two major signalling pathways induced by ErbB receptors in this cell line, i.e. the ERK/MAPK and PI3K pathways.
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This diversity of diseases can also result from disruption of metabolic and other cellular processes regulated by steroid hormone receptors via aberrant transcriptional regulation.
To investigate the cellular processes regulated by acetylation in Y. lipolytica, we used Cytoscape software to establish the protein protein interaction network (Fig. 10).
In addition, the genes and cellular processes regulated by Class III HD ZIPs are poorly understood.
Based on these activities, we anticipate that tese compounds should be useful to probe other biochemical pathways and cellular processes regulated by K63 polyubiquitylation and to test their effects in relevant models of human pathologies in which these processes are dysregulated.
The cellular processes regulated by many of these EBPs remain unknown.
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