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Here we demonstrate that confinement of chromosomal domains to specific cellular positions has a strong influence on the spatial arrangement of the chromosome in the cell.
This diffusion through extracellular space is quantized more finely than the discretization imposed by the cellular positions alone.
HAMSB increased the rate of apoptosis compared with LAMS in cells in the distal colon in cellular positions 7 12, 14 15 and 17; compared with LAMST in cellular positions 11 12 and compared with HAMS in cellular positions 1 2, 11 12, 14 15 and 17.
Genetic loci occupy predictable cellular positions that change over time (Nielsen et al., 2006b; Viollier et al., 2004; Wang et al., 2005, 2006).
HAMSB increased the rate of apoptosis in a dose-related manner in cells in the distal colon in cellular positions 1 to 20, with the effect being most marked from the base of the crypt (position 1) to around position 15 (Fig. 3 ).
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These response gradients demonstrate the importance of the cellular position to determine the cellular response, or positional information.
However, global positioning system (GPS) and cellular positioning system (CPS), two representative positioning technologies applied in many scenarios of daily life, still have some drawbacks [4 7].
On the basis of the received signal strength from each valid AP, and embedded algorithms, the typical accuracy of Wi-Fi positioning is in the order of tens of meters in metropolitan areas, which is more accurate than other cellular positioning technologies, because Wi-Fi APs are more closely spaced than cellular network base stations.
Recently, it was demonstrated that SYT-SSX2 disrupted cellular positioning by remodeling the cytoskeleton and altering both cytoarchitecture and microtubule stability.
Therefore, we can follow the onset of DNA replication by following the cellular position of the origin bound to the ParB segregation factor.
Although disturbed cleavage angles in notochord cells expressing Eph4ΔC may not fully explain its drastic effects on cellular positioning and morphology, this data is consistent with the idea that diminished apicobasal polarity results in mispositioning of daughter cells during cell division and affects subsequent cellular intercalation.
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